研究実績
RESEARCH PERFORMANCE

生体機能材料学分野 教授 博士(工学) 山本 雅哉

学術論文(査読あり)

1. K. Kato, M. Yamamoto, and Y. Ikada. Ultrastructure of the interface between cultured osteoblasts and polymer substrates carrying organophosphate graft chains, Bioceramics 9, T. Kokubo ed., Elsevier Science LTD, Oxford, (1996), 383-386.
2. M. Yamamoto, K. Kato, and Y. Ikada. Effect of the structure of bone morphogenetic protein carriers on ectopic bone regeneration, Tissue Engineering, 2, 4, (1996), 315-326.
3. M. Yamamoto, K. Kato, and Y. Ikada. Ultrastructure of the interface between cultured osteoblasts and surface-modified polymer substrates. Journal of Biomedical Materials Research, 37, 1, (1997), 29-36.
4. L. Hong, Y. Tabata, M. Yamamoto, S. Miyamoto, K. Yamada, N. Hashimoto, and Y. Ikada. Comparison of bone regeneration by bone morphogenetic protein incorporated in biodegradable hydrogel and in solution. Journal of Biomaterials Science, Polymer Edition, 9, 9, (1998), 1001-1014.
5. Y. Tabata, M. Yamamoto, and Y. Ikada. Biodegradable hydrogels for bone regeneration through growth factor release. Pure and Applied Chemistry, 70, 6, (1998), 1277-1282.
6. M. Yamamoto, Y. Tabata, and Y. Ikada. Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein. Journal of Biomaterials Science, Polymer Edition, 9, 5, (1998), 439-458.
7. Y. Tabata, M. Yamamoto, and Y. Ikada. Comparison of release profiles of various growth factors from biodegradable carriers. Materials Research Society Symposium Proceedings, 530, R. C. Thomson, D. J. Mooney, K. E. Healy, Y. Ikada, and A. G. Mikos eds., Material Research Society, Pennsylvania, (1998), 13-18.
8. 山本雅哉, 田畑泰彦, 筏 義人. ポリイオンコンプレックスを利用したヒドロゲルからの種々の細胞増殖因子の徐放化. Drug Delivery System, 14, 6, (1999), 506-510.
9. Y. Tabata, M. Miyao, M. Yamamoto, and Y. Ikada. Vascularization into porous sponge by sustained release of basic fibroblast growth factor. Journal of Biomaterials Science, Polymer Edition, 10, 9, (1999), 957-968.
10. M. Yamamoto, Y. Tabata, and Y. Ikada. Growth factor release from gelatin hydrogel for Tissue Engineering. Journal of Bioactive Compatible Polymers, 14, 6, (1999), 474-489.
11. 洪 流, 田畑泰彦, 山本雅哉, 宮本 享, 橋本信夫, 筏 義人. TGF-β1含有吸収性ゼラチンハイドロゲルの頭蓋骨再生能. Drug Delivery System, 14, 1, (1999), 43-50.
12. 山本雅哉, 田畑泰彦, 筏 義人. 組織再生のための細胞成長因子のゼラチンヒドロゲルからの徐放, 生体材料, 18, 4, (2000), 194-200.
13. M. Yamamoto, Y. Tabata, L. Hong, S. Miyamoto, N. Hashimoto, and Y. Ikada. Bone regeneration by transforming growth factor β1 released from a biodegradable hydrogel. Journal of Controlled Release, 64 , 1-3, (2000), 133-142.
14. L. Hong, Y. Tabata, S. Miyamoto, M. Yamamoto, K. Yamada, N. Hashimoto, and Y. Ikada. Bone regeneration at rabbit skull defects treated with transforming growth factor-β1 incorporated into hydrogels with different levels of biodegradability. Journal of Neurosurgery, 92, 2, (2000), 315-325.
15. M. Yamamoto, Y. Tabata, H. Kawasaki, and Y. Ikada. Promotion of fibrovascular tissue ingrowth into porous sponges by basic fibroblast growth factor. Journal of Materials Science: Materials in Medicine , 11, 4, (2000), 213-218.
16. K. Kato, Y. Kikumura, M. Yamamoto, N. Tomita, S. Yamada, and Y. Ikada. Collagen immobilization onto the surface of artificial hair for improving the tissue adhesion. Journal of Adhesion Science and Technology, 14, 5, (2000), 635-650.
17. M. Yamamoto, Y. Ikada, and Y. Tabata. Controlled release of growth factors based on biodegradation of gelatin hydrogel. Journal of Biomaterials Science, Polymer Edition, 12, 1, (2001), 77-88.
18. H. Ueda, L. Hong, M. Yamamoto, K. Shigeno, M. Inoue, T. Toba, M. Yoshitani, T. Nakamura, Y. Tabata, and Y. Shimizu. Use of collagen sponge incorporating transforming growth factor-β1 to promote bone repair in skull defects in rabbits. Biomaterials, 23, 4, (2001), 1003-1010.
19. Y. Sakakibara, K. Nishimura, K. Tambara, M. Yamamoto, F. Lu, Y. Tabata, and M. Komeda. Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation. The Journal of Thoracic and Cardiovascular Surgery, 124, 1, (2002), 50-56.
20. T. Okamoto, Y. Yamamoto, M. Gotoh, D. Liu, M. Kihara, K. Kameyama, E. Hayashi, K. Nakamura, A. Yamauchi, C.-L. Huang, H. Yokomise, M. Yamamoto, T. Nakamura, Y. Shimizu, and Y. Tabata. Cartilage regeneration using slow release of bone morphogenetic protein-2 from a gelatin sponge to treat experimental canine tracheomalacia: a preliminary report. ASAIO Journal, 49, 1, (2003), 63-69.
21. M. Yamamoto, Y. Sakakibara, K. Nishimura, M. Komeda, and Y. Tabata. Improved therapeutic efficacy in cardiomyocyte transplantation for myocardial infarction with release system of basic fibroblast growth factor. Artificial Organs, 27, 2, (2003), 181-198.
22. H. Ueda, T. Nakamura, M. Yamamoto, N. Nagata, S. Fukuda, Y. Tabata, and Y. Shimizu. Repairing of rabbit skull defect by dehydrothermally crosslinked collagen sponges incorporating transforming growth factor β1. Journal of Controlled Release., 88, 1, (2003), 55-64.
23. Y. Sakakibara, K. Tambara, G. Sakaguchi, F. Lu, M. Yamamoto, K. Nishimura, Y. Tabata, and M. Komeda. Toward surgical angiogenesis using slow-released basic fibroblast growth factor. European Journal of Cardio-Thoracic Surgery, 24, 1, (2003), 105-112.
24. M. Yamamoto, Y. Takahashi, and Y. Tabata. Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein. Biomaterials, 24, 24, (2003), 4375-4383.
25. Y. Yamamoto, T. Okamoto, M. Goto, H. Yokomise, M. Yamamoto, and Y. Tabata. Experimental study of bone morphogenetic protein-2 slow release from an artificial trachea made of biodegradable materials: evaluation of stenting time. ASAIO Journal, 49, 5, (2003), 533-536.
26. 中野貴由, 土田裕基, 石本卓也, 藤谷 渉, 馬越佑吉, 出口博史, 山本 融, 野口真一, 山本雅哉, 川上 理, 田畑泰彦, 山本敏男. 生体硬組織への結晶学的アプローチ -微小領域X線回折法ならびにSpring-8放射光施設によって-. Boundary, 19, 9, (2003), 16-20.
27. 高松聖仁, 中塚洋直, 今井祐記, 越宗 勝, 金城養典, 榎本 誠, 高岡邦夫, 田畑泰彦, 山本雅哉, 筏 義人. 生体吸収性ポリマーチューブによるbFGF Drug Delivery Systemの末梢神経再生への応用. 移植, 39, 3, (2004), 353.
28. H. Takita, J. W.M. Vehof, J. A. Jansen, M. Yamamoto, Y. Tabata, M. Tamura, and Y. Kuboki. Carrier dependent cell differentiation of bone morphogenetic protein-2 induced osteogenesis and chondrogenesis during the early implantation stage in rats. Journal of Biomedical Materials Research Part A, 71, 1, (2004), 181-189.
29. A. Kanematsu, A. Marui, S. Yamamoto, M. Ozeki, Y. Hirano, M. Yamamoto, O. Ogawa, M. Komeda, and Y. Tabata. Type I collagen can function as a reservoir of basic fibroblast growth factor. Journal of Controlled Release, 99, 2, (2004), 281-292.
30. T. Ishimoto, T. Nakano, Y. Umakoshi, M. Yamamoto, and Y. Tabata. Effects of applied stress on preferential alignment of biological apatite in rabbit forelimb bones. Phosphorus Research Bulletin, 17, (2004), 77-82.
31. M. Yamamoto, Y. Takahashi, and Y. Tabata. Bone induction by controlled release of BMP-2 from a biodegradable hydrogel in various animal species -From mouse to non-human primate-. Key Engineering Materials, 288-289, (2005), 253-256.
32. Y. Takahashi, M. Yamamoto, and Y. Tabata. Osteogenic differentiation of mesenchymal stem cells in biodegradable sponges composed of gelatin and β-tricalcium phosphate. Biomaterials, 26, 17, (2005), 3587-3596.
33. Y. Takahashi, M. Yamamoto, and Y. Tabata. Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponges composed of gelatin and b-tricalcium phosphate, Biomaterials, 26, 23, (2005), 4856-4865.
34. G. Sakaguchi, K. Tambara, Y. Sakakibara, M. Ozeki, M. Yamamoto, G. Premaratne, X. Lin, K. Hasegawa, Y. Tabata, K. Nishimura, and M. Komeda. Control-released hepatocyte growth factor prevents the progression of heart failure in stroke-prone spontaneously hypertensive rats. The Annals of Thoracic Surgery, 79, 5, (2005), 1627-1634.
35. M. Yamamoto, Y. Takahashi, A. Hokugo, and Y. Tabata. Enhanced osteoinduction by biodegradable gelatin-b-tricalcium phosphate sponge capable for bone morphogenetic protein release. Journal of Hard Tissue Biology, 14, 2, (2005), 286-287.
36. A. Marui, A. Kanematsu, K. Yamahara, K. Doi, T. Kushibiki, M. Yamamoto, H. Itoh, T. Ikeda, Y. Tabata, and M. Komeda. Simultaneous application of basic fibroblast growth factor and hepatocyte growth factor to enhance the blood vessels formation. Journal of Vascular Surgery, 41, 1, (2005), 82-90.
37. Y. Takahashi, M. Yamamoto, and Y. Tabata. Design of an osteoinductive biodegradable cell scaffold based on controlled release technology of bone morphogenetic protein. Israel Journal of Chemistry, 45, 4, (2005), 465-475.
38. K. Tambara, G. U. Premaratne, G. Sakaguchi, N. Kanemitsu, X. Lin, H. Nakajima, Y. Sakakibara, Y. Kimura, M. Yamamoto, Y. Tabata, T. Ikeda, and M. Komeda. Administration of control-released hepatocyte growth factor enhances the efficacy of skeletal myoblast transplantation in rat infarcted hearts by greatly increasing both quantity and quality of the graft. Circulation, 112, 9 Supplement, (2005), I129-I134.
39. J. Tazaki, T. Akazawa, M. Murata, M. Yamamoto, Y. Tabata, R. Yoshimoto, and M. Arisue. BMP-2 dose-response and release studies in functionally graded HAp. Archives of BioCeramics Research, 5, (2005), 182-185.
40. Y. Takahashi, M. Yamamoto, and Y. Tabata. Enhanced bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel. Tissue Engineering, 12, 5, (2006), 1305-1311.
41. H. Hosseinkhani, M. Yamamoto, Y. Inatsugu, Y. Hiraoka, S. Inoue, H. Shimokawa, and Y. Tabata. Enhanced ectopic bone formation using a combination of plasmid DNA impregnation into 3-D scaffold and bioreactor perfusion culture. Biomaterials, 27, 8, (2006), 1387-1398.
42. T. Nakano, T. Ishimoto, J.-W. Lee, Y. Umakoshi, M. Yamamoto, Y. Tabata, A. Kobayashi, H. Iwaki, K. Takaoka, M. Kawai, and T. Yamamoto. Crystallographic approach to regenerated and pathological hard tissues. Materials Science Forum, 512, (2006), 255-260.
43. T. Ishimoto, T. Nakano, Y. Umakoshi, M. Yamamoto, and Y. Tabata. Role of stress distribution on healing process of preferential alignment of biological apatite in long bones. Materials Science Forum, 512, (2006), 261-264.
44. J.-W. Lee, T. Nakano, S. Toyosawa, N. Ijuhin, Y. Tabata, M. Yamamoto, and Y. Umakoshi. Role of osteoclast in preferential alignment of biological apatite (BAp) in long bones. Materials Science Forum, 512, (2006), 265-268.
45. H. Igai, S.S. Chang, M. Gotoh, Y. Yamamoto, N. Misaki, T. Okamoto, M. Yamamoto, Y. Tabata, and H. Yokomise. Regeneration of canine tracheal cartilage by slow release of basic fibroblast growth factor from gelatin sponge. ASAIO Journal, 52, 1, (2006), 86-91.
46. J. Jo, M. Yamamoto, K. Matsumoto, T. Nakamura, and Y. Tabata. Liver targeting of plasmid DNA with a cationized pullulan for tumor suppression. Journal of Nanoscience and Nanotechnology, 6, 9-10, (2006), 2853-2859.
47. I. Kanatani, T. Ikai, A. Okazaki, J. Jo, M. Yamamoto, M. Imamura, A. Kanematsu, S. Yamamoto, N. Ito, O. Ogawa, and Y. Tabata. Efficient gene transfer by pullulan-spermine occurs through both clathrin- and raft/caveolae-dependent mechanisms. Journal of Controlled Release., 116, 1, (2006), 75-82.
48. M. Yamamoto and Y. Tabata. Tissue Engineering by modulated gene delivery. Advanced Drug Delivery Reviews, 58, (2006), 535-554.
49. 丸井 晃, 田畑泰彦, 福島雅典, 北 徹, 中尾一和, 木村 剛, 伊藤 裕, 松井茂之, 長谷川浩二, 堀内久徳, 原田昌樹, 山本雅哉, 小島伸介, 仁科 健, 池田 義, 米田正始. bFGF徐放による「時間的,空間的」局所血管新生 -安全性,低侵襲性への新たなる試み-. Cardiovascular Med-Surg, 8, 2, (2006), 83-87.
50. 望月祐一, 朝村真一, 草田朗子, 森 廣政, 松永吉真, 山本雅哉, 田畑泰彦, 磯貝典孝. BMP-2含浸ゼラチンハイドロゲルシートを用いた骨再生 ―イヌ眼窩床骨折モデルへの応用―. 再生医療, 6, 1, (2007), 20-26.
51. 城 潤一郎, 三島史人, 武田真一, 山本雅哉, 村垣善浩, 伊関 洋, 佐保典英, 窪田 純, 佐々木 明, 西嶋茂宏, 田畑泰彦. 深部治療に対応したナノ磁性体を応用した次世代DDS型治療システム, Drug Delivery System, 22, 5, (2007), 558-568.
52. M. Yamamoto, K. Yanase, and Y. Tabata. Fabrication of three-dimensional cell scaffolds with spatial gradients of biomolecules. Inflammation and Regeneration, 27, (2007), 102-106.
53. M. Murata, T. Akazawa, T. Sasaki, K. Ito, J. Tazaki, M. Yamamoto , Y. Tabata, and M. Arisue. Blood Permeability of a Novel Ceramic Scaffold for BMP-2. Journal of Biomedical Materials Research Part B: Applied Biomaterials , 81, 2, (2007), 469-475.
54. Y. Takahashi, M. Yamamoto, K. Yamada, O. Kawakami, and Y. Tabata. Skull bone regeneration in non-human primates by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel. Tissue Engineering, 13, 2, (2007), 293-300.
55. J. Liu, S. Ohta, A. Sonoda, M. Yamada, M. Yamamoto, N. Nitta, K. Murata, and Y. Tabata. Preparation of PEG-conjugated fullerene containing Gd3+ ions for photodynamic therapy. Journal of Controlled Release, 117, 1, (2007), 104-110.
56. J. Jo, T. Ikai, A. Okazaki, K. Nagane, M. Yamamoto, Y. Hirano, and Y. Tabata. Expression profile of plasmid DNA by spermine derivatives of pullulan with different molecular weights . Journal of Biomaterials Science, Polymer Edition, 18, 7, (2007), 883-899.
57. J. Jo, T. Ikai, A. Okazaki, K. Nagane, M. Yamamoto, Y. Hirano, and Y. Tabata. Expression profile of plasmid DNA by spermine derivatives of pullulan with different extents of spermine introduced. Journal of Controlled Release, 118, 3, (2007), 389-398.
58. H. Igai, Y. Yamamoto, S.S. Chang, M. Yamamoto, Y. Tabata, and H. Yokomise. Tracheal cartilage regeneration by slow release of basic fibroblast growth factor from a gelatin sponge. The Journal of Thoracic and Cardiovascular Surgery, 134, 1, (2007), 170-175.
59. A. Marui, Y. Tabata, S. Kojima, M. Yamamoto, K. Tambara, T. Nishina, Y. Saji, K. Inui, T. Hashida, S. Yokoyama, R. Onodera, T. Ikeda, M. Fukushima, and M. Komeda. A novel approach to therapeutic angiogenesis for patients with critical limb ischemia by sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel: an initial report of the phase I-IIa study. Circulation Journal, 71, 8, (2007), 1181-1186.
60. T. Ishimoto, T. Nakano, Y. Umakoshi, M. Yamamoto, and Y. Tabata. Change in Material and Structural Parameters of Bone Mechanical Function during Long-Bone Regeneration. Materials Science Forum, 561-565, (2007), 1451-1454.
61. J. Tazaki, T. Akazawa, M. Murata, M. Yamamoto, Y. Tabata, J. Hino, M. Arisue, and T. Shibata. Comparison of HAp and β-TCP in BMP-2 Dose-response and Release Study. Key Engineering Materials, 361-363, (2008), 1033-1036.
62. Z. S. Patel, H. Ueda, M. Yamamoto, Y. Tabata, and A. G. Mikos. In vitro and in vivo release of vascular endothelial growth factor from gelatin microparticles and biodegradable composite scaffolds. Pharmaceutical Research, 25, 10, (2008), 2370-2378.
63. Z. S. Patel, M. Yamamoto, H. Ueda, Y. Tabata, and A. G. Mikos. Biodegradable gelatin microparticles as delivery systems for the controlled release of bone morphogenetic protein-2. Acta Biomaterialia, 4, 5, (2008), 1126-1138.
64. H. Igai, S. S. Chang, M. Gotoh, Y. Yamamoto, M. Yamamoto, Y. Tabata, and H. Yokomise. Tracheal cartilage regeneration and new bone formation by slow release of bone morphogenetic protein (BMP)-2. ASAIO Journal, 54, 1, (2008), 104-108.
65. S. Nishijima, S. Takeda, F. Mishima, Y. Tabata, M. Yamamoto, J. Jo, H. Iseki, Y. Muragaki, A. Sasaki, K. Jun, and N. Saho. A study of magnetic drug delivery system using bulk high temperature superconducting magnet. IEEE Transaction on Applied Superconductivity, 18, 2, (2008), 874-877.
66. N. Nishishita, J. Jo, M. Yamamoto, Y. Tabata, and Y. Hirano. The gene transfection using cell attachment peptides for gene therapy. Peptide Science, 2007, (2008), 443-446.
67. G. Matsumoto, Y. Omi, E. Kubota, S. Ozono, H. Tsuzuki, Y. Kinoshita, M. Yamamoto, and Y. Tabata. Enhanced regeneration of critical bone defects using a biodegradable gelatin sponge and β-tricalcium phosphate with bone morphogenetic protein-2. Journal of Biomaterials Applications, 24, 4, (2009), 327-342.
68. X. Lin, K. Tambara, M. Fu, M. Yamamoto, G.U. Premaratne, Y. Sakakibara, A. Marui, T. Ikeda, M. Komeda, and Y. Tabata. Controlled Release of Matrix Metalloproteinase 1 with or without Skeletal Myoblasts Transplantion Improves Cardiac Function of Rat Hearts with Chronic Myocardial Infarction. Tissue Engineering Part A, 15, 9, (2009), 2699-2706.
69. H. Igai, S. S. Chang, M. Gotoh, Y. Yamamoto, M. Yamamoto, Y. Tabata, and H. Yokomise. Widespread and Early Tracheal Cartilage Regeneration by Synchronous Slow Release of b-FGF and BMP-2. ASAIO Journal, 55, 3, (2009), 266-270.
70. J.Tazaki, M. Murata, T. Akazawa, M. Yamamoto, K. Ito, M. Arisue, T. Shibata, and Y. Tabata. BMP-2 release and dose-response studies in hydroxyapatite and beta-tricalcium phosphate. Bio-Medical Materials and Engineering, 19, 2-3, (2009), 141-146.
71. X. Lin, H. Jo, T. M. Ishii, M. Fujita, M. Fu, K. Tambara, M. Yamamoto, Y. Tabata, M.Komeda, and S. Matsuoka. Controlled release of matrix metalloproteinase-1 plasmid DNA prevents left ventricular remodeling in chronic myocardial infarction of rats. Circulation Journal, 73, 12, (2009), 2315-2321.
72. M. Komeda, A. Marui, K. Tambara, M. Yamamoto, Y. Saji, T. Nishina, and Y. Tabata. Biologic anastomosis: the first case of biologic coronary bypass surgery. The Journal of Thoracic and Cardiovascular Surgery, 138, 3, (2009), 775-777.
73. H. Komobuchi, N. Hato, M. Teraoka, H. Wakisaka, H. Takahashi, K. Gyo, Y. Tabata, and M. Yamamoto. Basic fibroblast growth factor combined with biodegradable hydrogel promotes healing of facial nerve after compression injury: an experimental study. Acta Oto-Laryngologica, 130, 1, (2009), 173-178, 2009.
74. M. Yamamoto, D. James, H. Li, J. Butler, S. Rafii, and S.Y. Rabbany. Generation of Stable co-cultures of vascular cells in a honeycomb alginate scaffold. Tissue Engineering Part A, 16, 1, (2010), 299-308.
75. J. Jo, A. Okazaki, K. Nagane, M. Yamamoto, and Y. Tabata. Preparation of cationized polysaccharides as gene transfection carrier for bone marrow-derived mesenchymal stem cells. Journal of Biomaterials Science, Polymer Edition, 21, 2, (2010), 185-204.
76. J. Jo, K. Nagane, M. Yamamoto, and Y. Tabata. Effect of amine type on the expression of plasmid DNA by cationized dextran. Journal of Biomaterials Science, Polymer Edition, 21, 2, (2010), 225-236.
77. M. Yamamoto, K. Yanase, and Y. Tabata. Generation of Type I Collagen Gradient in Polyacrylamide Hydrogels by a Simple Diffusion-Controlled Hydrolysis of Amide Groups. Materials, 3, 4, (2010), 2393-2404.
78. S.Y. Rabbany, J. Pastore, M. Yamamoto, T. Miller, S. Rafii, R. Aras, and M. Penn. Continuous delivery of stromal cell-derived factor-1 from alginate scaffolds accelerates wound healing. Cell Transplantation, 19, 4, (2010), 399-408.
79. S. Asamura, Y. Mochizuki, M. Yamamoto, Y. Tabata, and N. Isogai. Bone regeneration using a BMP-2-saturated slow-release gelatin hydrogel sheet: evaluation in a canine orbital floor fracture model. Annals of Plastic Surgery, 64, 4, (2010), 496-502.
80. H. Kohara, S. Tajima, M. Yamamoto, and Y. Tabata. Angiogenesis induced by controlled release of neuropeptide substance P. Biomaterials, 31, 33, (2010), 8617-8625.
81. S.C. Leeuwenburgh, J. Jo, H. Wang, M. Yamamoto, J.A. Jansen, and Y. Tabata. Mineralization, biodegradation, and drug release behavior of gelatin/apatite composite microspheres for bone regeneration. Biomacromolecules, 11, 10, (2010), 2653-2659.
82. T. Nakagawa, T. Sakamoto, H. Hiraumi, Y.S. Kikkawa, N. Yamamoto, K. Hamaguchi, K. Ono, M. Yamamoto, Y. Tabata, S. Teramukai, S. Tanaka, H. Tada, R. Onodera, A. Yonezawa, K. Inui, and J. Ito. Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial. BMC Medicine, 8, (2010), 76.
83. J. Ratanavaraporn, S. Damrongsakkul, S. Kanokpanont, M. Yamamoto , and Y. Tabata. Osteogenic Differentiation of Bone-Marrow-Derived Stem Cells Cultured with Mixed Gelatin and Chitooligosaccharide Scaffolds. Journal of Biomaterials Science, Polymer Edition, 22, 8, (2011), 1083-1098.
84. T. Ishimoto, T. Nakano, M. Yamamoto, and Y. Tabata. Biomechanical evaluation of regenerating long bone by nanoindentation. Journal of Materials Science: Material in Medicine, 22, 4, (2011), 969-976.
85. P.W. Henderson, S.P. Singh, D.D. Krijgh, M. Yamamoto, D.C. Rafii, J.J. Sung, S. Rafii, S.Y. Rabbany, and J.A. Spector. Stromal-derived factor-1 delivered via hydrogel drug-delivery vehicle accelerates wound healing in vivo. Wound Repair and Regeneration, 19, 3, (2011), 420-425.
86. H. Toda, M. Yamamoto, H. Kohara, and Y. Tabata. Orientation-regulated immobilization of Jagged1 on glass substrates for ex vivo proliferation of a bone marrow cell population containing hematopoietic stem cells. Biomaterials, 32, 29, (2011), 6920-6928.
87. J. Liu, J. Jo, Y. Kawai, I. Aoki, C. Tanaka, M. Yamamoto, and Y. Tabata. Preparation of polymer-based multimodal imaging agent to visualize the process of bone regeneration. Journal of Controlled Release, 157, 3, (2012), 398-405.
88. K. Ohno, T. Akashi, Y. Tsujii, M. Yamamoto, and Y. Tabata. Blood clearance and biodistribution of polymer brush-afforded silica particles prepared by surface-initiated living radical polymerization. Biomacromolecules, 13, 3, (2012), 927-936.
89. J. Tazaki, M. Murata, T. Akazawa, M. Yamamoto, M. Arisue, T. Shibata, H. Nagayasu, and Y. Tabata. The effect of partial dissolution-​precipitation treatment on calcium phosphate ceramics in the release of BMP-​2 and osteoinduction. Journal of Hard Tissue Biology, 21, 4, (2012), 459-468.
90. T. Ishimoto, T. Nakano, Y. Umakoshi, M. Yamamoto, and Y. Tabata. Degree of biological apatite c-axis orientation rather than bone mineral density controls mechanical function in bone regenerated using rBMP-2. Journal of Bone Mineral Research, 28, 5, (2013), 1170-1179.
91. Y. Iwasaki, K. Katayama, M. Yoshida, M. Yamamoto, and Y. Tabata. Comparative physicochemical properties and cytotoxicity of polyphosphoester ionomers with bisphosphonates. Journal of Biomaterials Science, Polymer Edition, 24, 7, (2013), 882-895.
92. M. Yamamoto and Y. Tabata. Protein immobilization onto biomaterial surfaces to control cell behaviors for tissue regeneration. International Journal of Tissue Regeneration, 4, (2013), 36-40.
93. M. Yamamoto, S. Rafii, and S. Y. Rabbany. Scaffold biomaterials for nano-pathophysiology. Advanced Drug Delivery Reviews, 74, (2014), 104-114.
94. M. Kawago, T. Yoshimasu, Y. Tabata, M. Yamamoto, Y. Hirai, T. Kinoshita, and Y. Okamura. Intrapleural administration of gelatin-embedded, sustained-release basic fibroblast growth factor for the regeneration of emphysematous lungs in rats. The Journal of Thoracic and Cardiovascular Surgery, 147, 5, (2014), 1644-1649.
95. M. Yamamoto, Y. Ikada, and Y. Tabata. Ultrastructure of bone tissue ectopically regenerated by biodegradable hydrogels incorporating bone morphogenetic protein-2. Inflammation and Regeneration, 34, 1, (2014), 56-63.
96. M. Yamamoto, A. Hokugo, Y. Takahashi, T. Nakano, M. Hiraoka, and Y. Tabata. Combination of BMP-2-releasing gelatin/β-TCP sponges with autologous bone marrow for bone regeneration of X-ray-irradiated rabbit ulnar defects. Biomaterials, 56, (2015), 18-25.
97. N. Morimoto, N, Kakudo, M. Matsui, M. Ogura, T. Hara, K. Suzuki, M. Yamamoto, Y. Tabata, and K. Kusumoto. Exploratory clinical trial of combination wound therapy with a gelatin sheet and platelet-rich plasma in patients with chronic skin ulcers: study protocol. BMJ Open, 5, 5, (2015), e007733.
98. M. Watanabe, H. Li, A.G. Kim, A. Weilerstein, A. Radu, M. Davey, S. Loukogeorgakis, M.D. Sánchez, K. Sumita, N. Morimoto, M. Yamamoto, Y. Tabata, A. W. Flake. Complete tissue coverage achieved by scaffold-based Tissue Engineering in the fetal sheep model of Myelomeningocele. Biomaterials, 76, (2016), 133-143.
99. M. Kumagai, A. Marui, Y. Tabata, T. Takeda, M. Yamamoto, A. Yonezawa, S. Tanaka, S. Yanagi, T. Ito-Ihara, T. Ikeda, T. Murayama, S. Teramukai, T. Katsura, K. Matsubara, K. Kawakami, M. Yokode, A. Shimizu, and R. Sakata. Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia. Heart Vessels, 31, 5, (2016), 713-721.
100. H. Toda, M. Yamamoto, H. Uyama, and Y. Tabata. Fabrication of hydrogels with elasticity changed by alkaline phosphatase for stem cell culture. Acta Biomaterialia, 29, (2016), 215-227.
101. N. Morimoto, N. Kakudo, T. Ogura, T. Hara, M. Matsui, M. Yamamoto, Y. Tabata, and K. Kusumoto. Easy-to-use preservation and application of platelet-rich plasma in combination wound therapy with a gelatin sheet and freeze-dried platelet-rich plasma: a case report. ePlasty, 16, (2016), 202-207.
102. Effect of hydrogel elasticity and ephrinB2-immobilized manner on Runx2 expression of human mesenchymal stem cells. H. Toda, M. Yamamoto, H. Uyama, Y. Tabata. Acta Biomater., 58, (2017), 312-322.
103. Design of magnetic gene complexes as effective and serum resistant gene delivery systems for mesenchymal stem cells. T. Y. Zhang, J. H. Wu, Q. H. Xu, X. R. Wang, J. Lu, Y. Hu, J. Jo, M. Yamamoto, D. Ling, Y. Tabata, J. Q. Gao. Int. J. Pharm., 520, (2017), 1-13.

学術論文(査読なし)

1. 筏 義人, 山本雅哉, 田畑泰彦, 山田圭介, 宮本 享, 菊池晴彦. 吸収性高分子材料を用いた骨組織の再生. 日本化学繊維研究所講演集, 54, (1997), 59-66.
2. 山本雅哉, 田畑泰彦. 循環器領域の再生医学. ハートナーシング, 13 , (2000), 71-78.
3. 山本雅哉, 高橋佳丈, 田畑泰彦. 骨形成因子の徐放化とその骨形成作用. 日本化学繊維研究所講演集 , 59, (2002), 95-101.
4. 山本雅哉, 榊原裕, 丹原圭一, 西村和修, 米田正始, 田畑泰彦. 細胞増殖因子の徐放化ハイドロゲルを用いた心疾患治療の試み. Meeting Reports of The Poval Committee, 120, (2002), 41-48.
5. 山本雅哉. 細胞増殖因子の徐放化. 生体材料, 20, (2002) , 46-52.
6. 山本雅哉, 榊原裕, 西村和修, 米田正始, 田畑泰彦. 血管新生を誘導した虚血心筋の細胞移植治療. 日本炎症再生学会誌, 22, (2002), 187-193.
7. 山本雅哉, 田畑泰彦. 骨組織の再生. 遺伝子医学 , 6, (2002), 409-423.
8. 山本雅哉. 組織工学. 人工臓器, 31, (2002), 111-114.
9. 山本雅哉, 田畑泰彦. 細胞増殖因子の徐放化による骨組織の再生. 再生医療, 2, (2003), 19-26.
10. 田畑泰彦, 山本雅哉, 中野貴由, 馬越佑吉. 細胞増殖因子の徐放による骨再生と結晶学的アプローチによる評価, 日本結晶成長学会誌, 31, (2004), 59-68.
11. 中野貴由, 石本卓也, 李 志旭, 馬越祐吉, 山本雅哉, 田畑泰彦, 小林章郎, 岩城啓好, 高岡邦夫, 山本敏男. 骨の力学的機能とミネラルの配向. 日本バイオレオロジー学会誌, 18, (2004), 21-31.
12. 北郷明成, 山本雅哉, 田畑泰彦. 高分子ハイドロゲルを利用した細胞増殖因子の徐放化とその骨再生誘導活性. 日本化学繊維研究所講演集, 62, (2005), 107-114.
13. 山本雅哉, 田畑泰彦. 線維性慢性疾患に対する組織再生誘導治療. Drug Delivery System, 20, (2005), 110-117.
14. 山本雅哉, 田畑泰彦. 細胞増殖因子の徐放技術と組織再生誘導. 生体材料, 24, (2006), 176-185.
15. 山本雅哉, 田畑泰彦. 遺伝子導入研究に役立つDDS. バイオテクノロジージャーナル, 6, (2006), 563-565.
16. 田畑泰彦, 劉 健, 山本雅哉. がん光線力学療法のための水溶性高分子修飾フラーレンの合成. 日本化学繊維研究所講演集, 64, (2007), 61-69.
17. 山本雅哉, 田畑泰彦. DDSを用いた内科的再生医療, 遺伝子-細胞ハイブリッド治療-. 再生医療, 6, (2007), 45-50.
18. 山本雅哉, 田畑泰彦. 徐放化細胞増殖因子による骨再生誘導. THE BONE, 21, (2007), 39-44.
19. 山本雅哉. 細胞周辺環境としての機能性バイオマテリアル足場の開発. 生体材料, 29, (2011), 41-47.
20. 田畑泰彦, 村上裕子, 糸岡朝樹, 山本雅哉. 軟らかさの異なるハイドロゲル細胞培養基材の作製. 日本化学繊維研究所講演集, 68, (2011), 99-104.
21. 山本雅哉. 細胞足場材料. 再生医療, 11, (2012), 12-16.
22. 山本雅哉, 丸井 晃, 坂田隆造, 田畑泰彦. 細胞増殖因子徐放化による血管新生治療. 細胞, 44, (2012), 16-19.
23. 山本雅哉, 田畑泰彦. 再生医療におけるdrug delivery systemの応用. 整形 ,災害外科, 56, (2013), 477-486.
24. 山本雅哉. 細胞機能を発揮するための表面加工技術. 再生医療, 12, (2013), 243-246.
25. 稲生佳菜子, 山本雅哉, 田畑泰彦. 糖応答分解性ハイドロゲル粒子を用いた細胞凝集体の調製. 日本化学繊維研究所講演集, 70, (2013), a16/1-a16/5.
26. 山本雅哉, 田畑泰彦. 糖応答分解性ハイドロゲル粒子を含む細胞凝集体の調製. 日本化学繊維研究所講演集, 71, (2014), 1-5.
27. 田畑泰彦, 有本晃佑, 山本雅哉. 糖応答性ハイドロゲルを用いた3次元培養基材の調製.日本化学繊維研究所講演集 , 72, (2015), 1-5.
28. 山本雅哉, 田畑泰彦. ドラッグデリバリーシステムを利用した再生医療. バイオサイエンスとインダストリー, 74, (2016), 8-14.

著書

1. 山本雅哉, 田畑泰彦, 筏 義人. 機能応用編 3章 組織と器官 異所性の骨形成,「バイオミメティックスハンドブック」(長田義仁編, 株式会社エヌ・ティー・エス出版, 東京), (2000), 441-444.
2. 山本雅哉, 田畑泰彦. 骨組織の再生.「ドラッグデリバリーシステムDDS技術の新たな展開とその活用法」(田畑泰彦編, 株式会社メディカルドゥ, 大阪), (2003), 146-153.
3. 山本雅哉, 田畑泰彦. 遺伝子治療とターゲティング.「ドラッグデリバリーシステムDDS技術の新たな展開とその活用法」(田畑泰彦編, 株式会社メディカルドゥ, 大阪, (2003), 238-244.
4. 山本雅哉, 田畑泰彦. 慢性疾患治療. 「再生医療へのブレイクスルー」(田畑泰彦編, 株式会社メディカルドゥ, 大阪),(2004) , 266-272.
5. A. Marui, K. Doi, K. Tambara, Y. Sakakibara, K. Ueyama, A. Iwakura, M. Yamamoto, T. Ikeda, Y. Tabata, and M. Komeda. Basic fibroblast growth factor and angiogenesis. “Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches” (H. Mori and H.Matsuda Eds., Springer-Verlag, Tokyo), (2005) , 145-156.
6. 山本雅哉, 田畑泰彦. 高分子によるターゲティング. 「ウイルスを用いない遺伝子導入法の材料, 技術, 方法論の新たな展開」(原島秀吉, 田畑泰彦編集, メディカルドゥ, 大阪), (2006), 124-129.
7. 山本雅哉, 田畑泰彦. ティッシュエンジニアリングと遺伝子治療. 「ティッシュエンジニアリング2006」(田畑泰彦, 岡野光夫編集, 日本医学館, 東京),(2006) , 88-96.
8. 山本雅哉, 田畑泰彦. ドラッグデリバリーシステム(徐放化). 「再生医療のためのバイオマテリアル」(田畑泰彦編集, コロナ社, 東京), (2006) , 160-178.
9. 山本雅哉, 田畑泰彦. ティッシュエンジニアリングと内科的再生誘導治療. 「ティッシュエンジニアリング2007」(田畑泰彦, 岡野光夫編集, 日本医学館, 東京), (2007) , 153-160.
10. M. Yamamoto and Y. Tabata. Tissue Engineering of internal medicine for regeneration therapy of chronic fibrotic diseases. Topics in Tissue Engineering, 4: Chapter 2, (2008), 1-24.
11. 山本雅哉, 田畑泰彦. 傾斜機能性足場材料.「進みつづける細胞移植治療の実際 上巻 遺伝子医学MOOK別冊 −再生医療の実際に向けた科学, 技術と周辺要素の理解」(田畑泰彦編集, 株式会社メディカルドゥ, 大阪), (2008), 185-190.
12. 城潤一郎, 山本雅哉, 田畑泰彦. 細胞研究と細胞移植治療のための細胞トレーシング技術.「進みつづける細胞移植治療の実際 上巻 遺伝子医学MOOK別冊 −再生医療の実際に向けた科学, 技術と周辺要素の理解」(田畑泰彦編集, 株式会社メディカルドゥ, 大阪), (2008), 251-255.
13. 山本雅哉, 田畑泰彦. 第1章 細胞周辺環境のための材料化学技術 4. 複合材料. 「遺伝子医学MOOK別冊 ますます重要になる細胞周辺環境(細胞ニッチ)の最新科学技術」(田畑泰彦編集, 株式会社メディカルドゥ, 大阪), (2009), 71-76.
14. 山本雅哉, 田畑泰彦. 第2章 細胞周辺環境のための材料加工, 利用技術 15. 傾斜機能化技術. 「遺伝子医学MOOK別冊 ますます重要になる細胞周辺環境(細胞ニッチ)の最新科学技術」(田畑泰彦編集, 株式会社メディカルドゥ, 大阪), (2009), 169-174.
15. 山本雅哉, 田畑泰彦. 第4章 細胞周辺環境のための生物医学, 工学融合化学技術 2. 生体シグナル因子徐放化. 「遺伝子医学MOOK別冊 ますます重要になる細胞周辺環境(細胞ニッチ)の最新科学技術」(田畑泰彦編集, 株式会社メディカルドゥ, 大阪), (2009), 283-290.
16. 山本雅哉, 田畑泰彦. 生体吸収性ハイドロゲルを用いた生理活性物質の徐放化による骨再生. 「機能性食品素材の骨と軟骨への応用」(石見佳子, 上原万里子監修, シーエムシー出版, 東京), (2011), 11-24.
17. 山本雅哉, 田畑泰彦. DDS・徐放化技術. 「ものづくり技術からみる再生医療 —細胞研究, 創薬, 治療—」(田畑泰彦監修, シーエムシー出版, 東京), (2011), 87-98.
18. 山本雅哉. DDS法の利用. 「未来型人工関節を目指して —その歴史から将来展望まで—」 (吉川秀樹, 中野貴由, 松岡厚子, 中島義雄編集, 日本医学館, 東京), (2013), 294-298.
19. 山本雅哉, 田畑泰彦. 細胞研究(細胞足場, 細胞内徐放, 遺伝子導入). 「ここまで広がるドラッグ徐放技術の最前線 古くて新しいドラッグデリバリーシステム(DDS)」(田畑泰彦編集, メディカルドゥ, 大阪), (2013) , 314-320.
20. 山本雅哉, 田畑泰彦. 糖. 「ここまで広がるドラッグ徐放技術の最前線 古くて新しいドラッグデリバリーシステム(DDS)」(田畑泰彦編集, メディカルドゥ, 大阪), (2013), 345-350.
21. M. Yamamoto and Y. Tabata. Protocol of osteoblastic differentiation of BMSC in biodegradable scaffolds composed of gelatin and b-tricalcium phosphate. “A Manuals for Differentiation of Bone Marrow Derived Stem Cells to Specific Cell Types” (G. Khang, T. Shimizu, K. W. Ng Eds., Manuals in Biomedical Research, vol. 8, World Scientific Publishing Inc.), (2014), 83-90.
22. 山本雅哉. 骨形成因子徐放化ハイドロゲルによる骨再生の増強 —生体吸収性ハイドロゲルによる骨形成因子の徐放化—.「バイオマテリアル研究の最前線」(公益財団法人 日本金属学会, 仙台), (2014), 163-164.
23. 山本雅哉, 田畑泰彦. 第5章, 第4節 ゼラチンヒドロゲルを用いた再生医療. 「ゲルテクノロジーハンドブック」(中野 義夫監修, エヌ,ティー,エス, 東京), (2014) , 775-782.
24. 山本雅哉, 平野義明,熊代善一, 田畑泰彦. 基礎2. 「再生医療 用語ハンドブック」(日本再生医療学会 岡野光夫, 浅島 誠監修, メディカルトリビューン, 東京), (2015), 51-76.
25. 山本雅哉, 田畑泰彦. 第2章, 第1節, 機能性ハイドロゲルを用いた三次元足場材料の開発.「三次元ティッシュエンジニアリング 細胞の培養・操作・組織化から品質管理、脱細胞化まで(大政健史, 福田淳二監修, エヌ,ティー,エス, 東京), (2015), 59-66.
26. 山本雅哉. 7-3 足場材料, 細胞培養足場. 「バイオマテリアル」(岡野光夫監修, 田畑泰彦, 塙 隆夫編集, 東京化学同人, 東京), (2016) , 319-322.

生体機能材料学分野 准教授 博士(学術) 森本 展行

査読付き原著論文

1. M. Tsugita, N. Morimoto, M. Nakayama. SiO2 and TiO2 nanoparticles synergistically trigger macrophage inflammatory responses. Part. Fibre Toxicol. 14:11, 2017.
2. M. Tsugita, N. Morimoto, M. Tashiro, K. Kinoshita, M. Nakayama. SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation. Cell Reports 18, 1298–1311, 2017.
3. M. Suzuki, A. Imao, G. Mogami, R. Chishima, T. Watanabe, T. Yamaguchi, N. Morimoto, T. Wazawa. Strong Dependence of Hydration State of F-Actin on the Bound Mg2+/Ca2+ Ions. J. Phys. Chem B, 120, 6917-6928, 2016.
4. N. Morimoto, M. Wakamura, K. Muramatsu, S. Toita, M. Nakayama, W. Shoji, M. Suzuki, F. M. Winnik. Membrane translocation and organelle-selective delivery steered by polymeric zwitterionic nanospheres. Biomacromolecules. 17, 1523-1535, 2016.
5. T. Wazawa, N. Morimoto, T. Nagai, M. Suzuki. Rotational motion of rhodamine 6G tethered to actin through oligo (ethylene glycol) linkers studied by frequency-domain fluorescence anisotropy. Biophys. Physicobiol. 12, 87-102, 2015.
6. N. Morimoto, K. Muramatsu, S. M. Nomura, M. Suzuki. Trading polymeric microspheres: Exchanging DNA molecules via microsphere interaction. Colloids Surf. B: Biointerfaces 128, 94-99, 2015.
7. N. Morimoto, T. Wazawa, Y. Inoue, M. Suzuki. Dynamic transformations of self-assembled polymeric microspheres induced by AC voltage and shear flow. RSC Adv. 5, 14851-14857, 2015.
8. N. Morimoto, Y. Sasaki, K. Mitsunushi, E. Korchagina, T. Wazawa, X.-P. Qiu, S. M. Nomura, M. Suzuki, F. M. Winnik. Temperature-responsive telechelic dipalmitoylglyceryl poly(N-isopropylacrylamide) vesicles: real-time morphology observation in aqueous suspension and in the presence of giant liposomes. Chem. Commun. 50, 8350—8352, 2014.
9. N. Morimoto, K. Muramatsu, T. Wazawa, Y. Inoue, M. Suzuki. Self-assembled microspheres driven by dipole-dipole interactions: UCST-type transition in water. Macromol. Rapid. Commun. 35, 103-108, 2014.
10. T. Wazawa, S. Yasui, N. Morimoto, M. Suzuki. Proteomics identified nuclear N-myc downstream-regulated gene 1 as a prognostic tissue biomarker candidate in renal cell carcinoma.Biochim. Biophys. Acta Proteins and Proteomics 1834, 2620-2629, 2013.
11. N. Morimoto, M. Yamazaki, J. Tamada, K. Akiyoshi. Polysaccharide-Hair Cationic Polypeptide Nanogels: Self-Assembly and Enzymatic Polymerization of Amylose Primer-Modified Cholesteryl Poly(l-lysine). Langmuir 29, 7509–7514, 2013.
12. N. Morimoto, S. Hirano, H. Takahashi, S. Loethen, D. H. Thompson, K. Akiyoshi. Self-assembled pH-sensitive cholesteryl pullulan nanogel as a protein delivery vehicle. Biomacromolecules 14, 56-63, 2013.
13. K. Nagano, N. Alles, A. H. Mian, A. Shimoda, N. Morimoto, Y. Tamura, H. Shimokawa, K. Akiyoshi, K. Ohya, K. Aoki. The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-a-induced bone resorption lacunae on mouse calvariae. J. Bone Miner. Metab. 29, 671-681, 2011.
14. K. Shimba, K. Furuta, N. Morimoto, N. Tezuka, S. Sugimoto. Microwave absorption properties of polymer modified Ni-Zn ferrite nanoparticles. Mater. Trans. 52, 740-745, 2011.
15. K. Shimba, K. Furuta, N. Morimoto, N. Tezuka, S. Sugimoto. Magnetic Properties of Nanoparticle–Polymer Composites Prepared Using Surface Modification and Cross-Linking Reaction. Mater. Trans. 52, 486-490, 2011.
16. T. Wazawa, T. Sagawa, T. Ogawa, N. Morimoto, T. Kodama, M. Suzuki. Hyper-mobility of water around actin filaments revealed using pulse-field gradient spin-echo 1H NMR and fluorescence spectroscopy. Biochem. Biophys. Res. Commun. 404, 985–990, 2011.
17. G. Mogami, T. Wazawa, N. Morimoto, T. Kodama, M. Suzuki. Hydration properties of adenosine phosphate series as studied by microwave dielectric spectroscopy. Biophys. Chem. 154, 1–7, 2011.
18. S. Toita, N. Morimoto, K. Akiyoshi, Functional Cycloamylose as a Polysaccharide-Based Biomaterial: Application in a Gene Delivery System. Biomacromolecules 11, 397-401, 2010.
19. T. Hirakura, K. Yasugi, T. Nemoto, M. Sato, T. Shimoboji, Y. Aso, N. Morimoto, K. Akiyoshi. Hybrid hyaluronan hydrogel encapsulated nanogel as a protein nanocarrier: New system for sustained delivery of protein with a chaperone-like function. J. Controlled Rel. 142, 483-489, 2010.
20. S.Toita, Y.Soma, N. Morimoto, K.Akiyoshi. Cycloamylose-based Biomaterial: Nanogel of Cholesterol-bearing Cationic Cycloamylose for siRNA Delivery. Chem. Lett. 38, 1114-1115, 2009.
21. M.X. Chu, H. Kudo, T. Shirai, K, Miyajima, H. Saito, N. Morimoto , K. Yano, Y. Iwasaki, K. Akiyoshi, K. Mitsubayashi. A soft and flexible biosensor using a phospholipid polymer for continuous glucose monitoring. Biomed. Microdevices 11, 837-842, 2009.
22. Y. Ozawa, S. Sawada, N. Morimoto, K. Akiyoshi. Nanogel of hydrophobized dendritic dextrin for protein delivery. Macromol. Biosci. 9, 694-701, 2009 .
23. H. Kobayashi, O. Katakura, N. Morimoto, K. Akiyoshi, S. Kasugai Effects of cholesterol-bearing pullulan (CHP)-nanogels in combination with prostaglandin E1 on wound healing. J. Biomed. Mater. Res. B. 91B.1 55-60, 2009.
24. N. Morimoto, J. Tamada, S. Sawada, N. Shimada, A. Kano, A. Maruyama, K. Akiyoshi. Interaction of Self-assembled Cationic Nanogels with Oligo-DNA and Function as Artificial Nucleic Acid Chaperone. Chem. Lett. 38, 496-497, 2009.
25. N. Morimoto, R. Obeid, S. Yamane, F. M. Winnik, K. Akiyoshi. Composite Nanomaterials by Self-assembly and Controlled Crystallization of Poly(2-isopropyl-2-oxazoline)-Grafted Polysaccharide. Soft Matter 5, 1597-1600, 2009.
26. N. Alles, N.S. Soysa, A. H. Mian, N. Tomomatsu, H. Saito, R. Baron, N. Morimoto, K. Aoki, K. Akiyoshi, K. Ohya. Polysaccharide nanogel delivery of a TNF-a and RANKL antagonist peptide allows systemic prevention of bone loss. Eur. J. Pharma. Sci. 37, 83-88, 2009.
27. N. Morimoto, N. Ogino, T. Narita, K. Akiyoshi. Enzyme-responsive artificial chaperone system with amphiphilic amylose primer. J. Biotechnology 140, 246-249, 2009.
28. N. Morimoto, X. P. Qiu, F. M. Winnik, K. Akiyoshi. Dual stimuli-responsive nanogels by self-assembly of polysaccharides lightly grafted with thiol-terminated poly(N-isopropylacrylamide) chains. Macromolecules 41, 5985-5987, 2008.
29. H. Kudo, T. Yagi, M. X. Chu, H. Saito, N. Morimoto, Y. Iwasaki, K. Akiyoshi, K. Mitsubayashi. Glucose sensor using a phospholipid polymer-based enzyme immobilization method. Anal. Bioanal. Chem. 391,1269-1274, 2008.
30. H. Ayame, N. Morimoto, K. Akiyoshi. Self-assembled cationic nanogels for intracellular protein delivery. Bioconjugate Chem. 19, 882-890, 2008.
31. N. Morimoto, T. Ohki, K. Kurita, K. Akiyoshi. Thermo-Responsive Hydrogels with Nanodomains: Rapid shrinking of nanogel-crosslinking hydrogel of poly (N-isopropyl acrylamide) Macromol. Rapid Commun. 29, 672-676, 2008.
32. E. Akiyama, N. Morimoto, P. Kujawa, Y. Ozawa, F. M. Winnik, K. Akiyoshi. Self-Assembled Nanogels of Cholesteryl-Modified Polysaccharides: Effect of the Polysaccharide Structure on Their Association Characteristics in the Dilute and Semidilute Regimes. Biomacromolecules 8, 2366-2373, 2007.
33. N. Kato, U. Hasegawa, N. Morimoto, Y. Saita, K. Nakashima, Y. Ezura, H. Kurosawa, K. Akiyoshi, M. Noda. Nanogel-Based Delivery System Enhances PGE2 Effects on Bone Formation. J. Cell. Biochem. 101, 1063-1070, 2007.
34. N. Morimoto, N. Ogino, T. Narita, S. Kitamura, K. Akiyoshi. Enzyme-Responsive Molecular Assembly System with Amylose-Primer Surfactants. J. Am. Chem. Soc. 129, 458-459, 2007.
35. N. Morimoto, F. M. Winnik, K. Akiyoshi. Botryoidal Assembly of Cholesteryl-Pullulan/ Poly(N-isopropylacrylamide) Nanogels. Langmuir 23, 217-223, 2007.
36. K. Kobayashi, K. Ohuchi, H. Hoshi, N. Morimoto, Y. Iwasaki, S. Takatani, Segmented polyurethane modified by photopolymerization and cross-linking with 2-methacryloyloxyetyl phosphorylcholine polymer for blood-contacting surfaces of ventricular assist devices. J. Artif. Organs 8, 237-244, 2005.
37. N. Morimoto, T. Endo, M. Ohtomi, Y. Iwasaki, K. Akiyoshi, Hybrid Nanogels with Physical and Chemical Cross-Linking Structures as Nanocarriers. Macromol. Biosci. 5, 710-716, 2005.
38. N. Morimoto, T. Endo, Y. Iwasaki, K. Akiyoshi, Design of Hybrid Hydrogels with Self-Assembled Nanogels as Cross-Linkers: Interaction with proteins and Chaperone-Like Activity. Biomacromolecules 6, 1829-1834, 2005.
39. O. Katakura, N. Morimoto, Y. Iwasaki, K. Akiyoshi, S. Kasugai, Evaluation of 2- methacryloyloxyethyl phosphorylcholine (MPC) polymer-coated dressing on surgical wounds. J. Med. Dent. Sci. 52, 115-121, 2005.
40. N. Morimoto, A. Watanabe, Y. Iwasaki, K. Akiyoshi, K. Ishihara. Nano-scale surface modification of a segmented polyurethane with a phospholipid polymer. Biomaterials 25, 5353-5361, 2004.
41. Y. Iwasaki, K. Shimakata, N. Morimoto, K. Kurita. Hydrogel-like elastic phosphorylcholine polymer and a segmented polyurethane. J. Polym. Sci. A: Polym Chem 41, 68-75, 2003.
42. N. Morimoto, Y. Iwasaki, N. Nakabayashi, K. Ishihara. Physical properties and blood compatibility of surface-modified segmented polyurethane by semi-interpenetrating polymer networks with a phospholipid polymer. Biomaterials 23, 4881-4887, 2002.
43. Y. Iwasaki, S. Uchiyama, K. Kurita, N. Morimoto, N. Nakabayashi. A nonthrombogenic gas-permeable membrane composed of a phospholipid polymer skin film adhered to a polyethylene porous membrane. Biomaterials 23, 3421-3427, 2002.
44. 森本 展行、佐藤 育恵、渡辺 昭彦、中林 宣男、岩崎 泰彦、石原 一彦. リン脂質ポリマーを修飾したステンレス鋼表面の安定性と血液適合性. 高分子論文集 59, 432-437, 2002.
45. Y. Iwasaki, Y. Aiba, N. Morimoto, N. Nakabayashi, K Ishihara. Semi-interpenetrating polymer networks composed of biocompatible phospholipid polymer and segmented polyurethane. J Biomed Mater Res., 52, 701-708, 2000.

著書

1. N. Morimoto, K. Akiyoshi. Self-assembled nanogel Engineering. R. M. Ottenbrite, K. Park, T. Okano Eds., Biomedical Applications of Hydrogels Handbook. Springer, pp339-350, 2010.
2. 森本展行、秋吉一成.ナノゲル基盤ゲル材料.次世代医療のための高分子材料工学. シーエムシー出版 2008, pp.33-41.
3. 森本展行、秋吉一成. ナノゲル. ナノバイオ大辞典. テクノシステム. pp373-375, 2007.
4. N. Morimoto, S. M. Nomura, N. Miyazawa, K. Akiyoshi. Nanogel Engineered Designs for Polymeric Drug Delivery. S. Svenson Ed., Polymeric Drug Delivery Volume II - Polymeric Matrices and Drug Particle Engineering ACS Symposium Series 924. American Chemical Society, pp88-101, 2006.
5. N. Morimoto, K. Akiyoshi, Smart Polymer Nano- and Microgels: Synthesis and Applications. R. Arshady Ed., The MML series vol.8 Citus Books pp159-182, 2006.
6. N. Morimoto, U. Hasegawa, A. Sugawara, S. Yamane, K. Akiyoshi, Polysaccharide nanogel engineering: Design of nano-structured hydrogel materials and application to biotechnology nad medicine: Nanotechnology in Carbohydrate Chemistry. H. Yuasa Ed., Transworld Research Network pp.67-87, 2006.
7. 森本 展行、秋吉 一成. バイオインスパイアードマテリアル. 図解 高分子素材のすべて. 工業調査会 pp 126-129, 2005.
8. 森本 展行、秋吉 一成. 会合性多糖の設計と機能.糖鎖化学の最先端技術. シーエムシー出版. pp144-53, 2005.
9. 森本 展行、秋吉 一成. 高分子ナノゲルの設計とバイオ機能. ナノバイオテクノロジーの最前線 シーエムシー出版. pp44-52, 2003.

解説・研究報告

1. 森本展行、野村直之.バイオマテリアルとしての微粒子.バイオマテリアル:生体材料33, 278-283, 2015.
2. 森本展行、秋吉一成. ナノゲルDDS研究の最前線. ファルマシア 44(8), 764-768, 2008.
3. 森本 展行、秋吉 一成. ナノゲル架橋ゲルの設計と人工分子シャペロン機能. 高分子加工. 54, 38-43, 2005.
4. 森本展行、澤田晋一、岩崎泰彦、秋吉一成、ナノゲル工学:新規バイオマテリアルの開発. 生体材料工学研究所年報. 38, 21-23, 2004.

生体機能材料学分野 助教 博士(工学) 最上 譲二

論文

1. Physical Driving Force of Actomyosin Motility Based on the Hydration Effect, Makoto Suzuki, George Mogami, Hideyuki Ohsugi, Takahiro Watanabe, Nobuyuki Matubayasi, Cytoskeleton, in press, DOI: 10.1002/cm.21417, 2017
2. Strong Dependence of Hydration State of F-Actin on the Bound Mg2+/Ca2+ Ions, Makoto Suzuki, Asato Imao, George Mogami, Ryotaro Chishima, Takahiro Watanabe, Takaya Yamaguchi, Nobuyuki Morimoto, Tetsuichi Wazawa, J. Phys. Chem. B, 120, pp.6917-6928, 2016
3. Spatial-Decomposition Analysis of Energetics of Ionic Hydration, George Mogami, Makoto Suzuki, Nobuyuki Matubayasi, J. Phys. Chem. B, 120, pp1813-1821, 2016
4. Comparative Study on the Properties of Hydration Water of Na- and K-Halide Ions by Raman OH/OD-stretching Spectroscopy and Dielectric Relaxation Data, Yuichiro Okazaki, Tetsuo Taniuchi, George Mogami, Nobuyuki Matubayasi, Makoto Suzuki, J. Phys. Chem. A, 118, pp2922-2930, 2014
5. Anion-Dependence of Fast Relaxation Component in Na-, K-Halide Solutions at Low Concentrations Measured by High-Resolution Microwave Dielectric Spectroscopy, George Mogami, Takashi Miyazaki, Tetsuichi Wazawa, Nobuyuki Matubayasi, Makoto Suzuki, J. Phys. Chem. A, 117, pp4851-4862, 2013
6. Hydration-State Change of Horse Heart Cytochrome c Corresponding to Trifluoroacetic- Acid-Induced Unfolding, Yusuke Miyashita, Tetsuichi Wazawa, George Mogami, Satoshi Takahashi, Yoshihiro Sambongi, Makoto Suzuki, Biophys. J., 104, pp163-172, 2013
7. Role of Water in Actin-Myosin Binding and Actin Polymerization: Rotational and Translational Mobility of Water Molecules, Makoto Suzuki, Tetsuichi Wazawa, George Mogami, Takao Kodama, J. Phys. Soc. Jpn., 81, SA003, 2012
8. Hydration Properties of Adenosine Phosphate Series as Studied by Microwave Dielectric Spectroscopy, George Mogami, Tetsuichi Wazawa, Nobuyuki Morimoto, Takao Kodama, Makoto Suzuki, Biophys. Chem., 154, pp1-7, 2011
9. Measurement of the Dielectric Relaxation Property of Water-Ion Loose Complex in Aqueous Solutions of Salt at Low Concentrations, Takashi Miyazaki, George Mogami, Tetsuichi Wazawa, Takao Kodama, Makoto Suzuki, J. Phys. Chem. A, 112, pp10801-10806, 2008
10. Cooperative Structural Change of Actin Filaments Interacting with Activated Myosin Motor Domain, Detected with Copolymers of Pyrene-Labeled Actin and Acto-S1 Chimera Protein, Md Shahjahan P Siddique, George Mogami, Takashi Miyazaki, Eisaku Katayama, Taro Q P Uyeda, Makoto Suzuki, Biochem. Biophys. Res. Commun., 337, pp1185-1191, 2005
11. Dielectric and Fluoroscopic Study on the Dynamic Effects of Myosin-S1 with/without ATP on the Hyper-Mobile Water around Actin Filaments, *Makoto Suzuki, Md Shahjahan P Siddique, Takashi Miyazaki, George Mogami, Eisaku Katayama, Takao Kodama, Taro Q P Uyeda, FEBS J., 272, p336, 2005